parkinson’s
Disease Model

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parkinson’s
Disease Model

Neurix offers a versatile platform to accelerate development of Parkinson’s Disease (PD) drugs, providing in-depth characterisation during the hit-to-lead phase.

Our technology supports drug and compound screening, cell & gene therapy testing and mechanism-of-action studies.

By offering physiologically relevant insights into neurodegenerative processes, Neurix facilitates early-stage discovery and fosters therapeutic innovation.

OUR
parkinson’s
Disease Models

01.

iPSCs with α-synuclein mutation

• Dopaminergic differentiation
• 1 month culture as organoid

02.

Characterization

Decreased TH,  α-synuclein aggregates

DRUG TESTING
CHARACTERIsATION
& READOUTS  

Drug toxicity

Brain organoid growth: viability and proliferation

Organoid

  • Area
  • Volume
  • Roundness
  • Sphericity
  • Histology

Gene expression

  • cDNA array
  • RNA seq

Readouts

  • α-synuclein aggregates quantification
  • qPCR markers (MAP2, NeuN, LMX1A, TH)

Representative brightfield or fluorescence pictures of organoid from iPSC control or iPSC with A53T mutation in SNCA gene encoding α-synuclein at 1 month of culture. α-syn. Ab: α-synuclein antibody.