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Neuroimmune Sytem Modeling

Reflecting the MiniBrain™ technology application

Neurons and immune cells work in conjunction to combat intruding pathogens and injury. However, it is known that chronic activation of immune cells inside of the  CNS could be either a cause or a consequence of neurodegeneration and neuroinflammation. Therefore, immune cells represent a potential target for cellular and drug based therapy in various CNS diseases.
 

Implementing of engineered neural tissue allows an introduction of immune cells and facilitates to study an interaction between the nervous system and immune system in healthy state and pathology.

Example/show case:
Fig. 1 Engineered neural tissue including monocytes (0.5%) pre-stained with carboxyfluorescein succinimidyl ester (CFSE).

Fig. 2 Engineered neural tissue including monocytes (0.5%) visualized via IF: neurons (bIII tubulin, green), monocytes (Iba1, red).