Neuroimmune Sytem Modeling
Reflecting the MiniBrain™ technology application
Neurons and immune cells work in conjunction to combat intruding pathogens and injury. However, it is known that chronic activation of immune cells inside of the CNS could be either a cause or a consequence of neurodegeneration and neuroinflammation. Therefore, immune cells represent a potential target for cellular and drug based therapy in various CNS diseases.
Fig. 1 Engineered neural tissue including monocytes (0.5%) pre-stained with carboxyfluorescein succinimidyl ester (CFSE).
Fig. 2 Engineered neural tissue including monocytes (0.5%) visualized via IF: neurons (bIII tubulin, green), monocytes (Iba1, red).