HUMAN ORGANOID MODELS
ADVANTAGES OF PERSONALIZED SERVICE
HUMAN ORGANOID MODELS
Short-term and long-term compound testing
Highly physiological human 3-dimension tissues
High throughput and lead compound validation
Neurix offers customized services for organoid applications and drug discovery. Our experienced scientists are happy to work with you in order to understand your needs and meet your objectives. Below are examples of services that have been executed to meet specific needs.
ORGANOID GENERATION WITH CUSTOM IPSCS
Our expertise lies in generating organoids from your preferred IPS cell line, which are compatible with both high and low throughput for drug screening. Additionally, our organoids are suitable for compound validation with extended readouts.
CUSTOM ORGANOID MANUFACTURE
Flexibility is at the core of our services. We adeptly generate neural tissues from human stem cells, tailored to align with your unique research interests.
Additionally, Dopaminergic neurons (TH positive) as well as motor neurons (Foxp1 positive) can be generated.
MULTIPLE READOUTS ON ORGANOIDS
A high number of readouts can be applied for neuroscience research and may be adapted to higher throughput for drug discovery.
FLUORESCENT / LUMINESCENT REPORTER
For example, the fluorescent synapsin reporter for monitoring of neurotoxicity
CYTOTOXICITY AND NEUROTOXICITY TESTING
We perform routine cytotoxicity assays
We do cell sorting to quantify neural cell populations or purify newly generated cell lines
We performed genomic analysis in our glioblastoma invasion model
Performed deeper neuroscience investigation projects, as an example of glioblastoma invasion
DESIGN AND GENERATION OF CELL-BASED ASSAYS
Our scientists are delighted to meet with you and design a custom cell-based assay that precisely aligns with your specific needs. Currently, we are actively developing cell-based assays to accurately assess the quality of bio-active molecules in a cost-effective manner.
PERSONALIZED SERVICE - SERVICE SPECIFICATIONS
Field of application
- Mature tissue: Composed of neurons, astrocytes, and oligodendrocytes.
- Early tissue: Composed of Neurons, astrocytes, oligodendrocytes progenitors, and neural progenitors. The latter cells keep generating newborn neurons in a dynamic process.
- Embryoid tissue: Composed of endodermal, mesodermal and ectodermal cells.
Neurix’s Minibrain & Neurosphere technology with minimum batch-to-batch variability guaranteed by extensive quality control of identity (rt-qPCR)
Lead compound validation, high throughput screening & neuroscience Research
Short-term (7 days) to long-term (1.5 months)
Preynat-Seauve, O. et al. Development of human nervous tissue upon differentiation of embryonic stem cells in three-dimensional culture. Stem Cells Dayt. Ohio 27, 509–520 (2009).
Krug, A. K. et al. Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch. Toxicol. 87, 123–143 (2013).
VALIDATED ASSAYS AND PROTOCOLS
Personalized service is integrated into a variety of validated assays that can be implemented in drug development for efficacy evaluation of novel compounds:
Cell viability assays
Histological analysis (IHC & IF)
Cell sorting and cell population analysis (FACS)
At Neurix, we provide tailored services for various neural applications, such as gene/cell/polymer therapy testing, brain tumor drug testing, modeling neurodegenerative diseases, and conducting neurotoxicity assays. Our team of experienced scientists is dedicated to collaborating with you to comprehend your requirements and achieve your goals.
Phone: +41 22 379 46 43
Location: Avenue de la Roseraie 64
1205 Geneva, Switzerland